Morphogenesis control by mechanical stresses

How can cells coordinate the reproducible morphing of tissue into a desired shape? We develop a theoretical framework to describe the growth dynamics of cells within a tissue by reducing cells to their bulk mechanical properties and their position within the cell arrangement. This framework allows us to address how mechanical stresses arising within a tissue control the spatio-temporal dynamics of tissue growth. The aim of this project is to answer how mechanical stresses build up and regulate cell mechanics, cell divisions and biological messengers for reproducible, three-dimensional morphogenesis of tissues.