Selina Wilhelmi
Current and projects and student research topics:
- Analysis of SNPs in regulatory regions
- Database of regulatory SNPs and their impact on the binding of transcription factors
- Development of variant calling pipelines
- Database management and website development
Insight into one research project
A transcription factor binding site (TFBS) is a sequence site in the DNA where regulatory proteins can bind to. A single nucleotide polymorphism (SNP) in a TFBS can change the binding affinity. The upper strand shows the reference allele where the transcription factor (TF) can bind to the DNA, the lower strand shows the alternate allele where the binding is disabled.
